PWR can refer to:
Pratt & Whitney Rocketdyne Engineering
Power, a common abbreviation in Electronics.
Politechnika Wroclawska, or Wroclaw University of Technology
Pairwise Rankings, a common ranking system used to achieve collegiete sports seeding
Pressurized water reactor, a type of nuclear power reactor
PAHO/WHO Representation, the staff and facilities associated with a regional office of the Pan-American Health Organization
The Preston and Wyre Railway, a historic railway company in Lancashire, England
PWR