Metamizole sodium is a non-steroidal anti-inflammatory drug (NSAID), commonly used in the past as a powerful painkiller and fever reducer. It is better known under the names Dipyrone, Analgin and Novalgin.Metamizole was first synthesized by the German company Hoechst AG in 1920, and its mass production started in 1922. It remained freely available worldwide until the 1970s, when it was discovered that the drug carries a small risk of causing agranulocytosis - a very dangerous and potentially fatal condition. Controversy remains regarding the level of risk. Several national medical authorities have banned metamizole either totally or have restricted it to be available only on prescription.
Risks of agranulocytosis
According to comments by Dr Anthony Wong of the University of S├úo Paulo, Brazil in a WHO newsletter, Dr Anthony Wong in WHO Pharmaceuticals Newsletter No. 1, 2002, p.15 recent studies estimate that the incidence rate of metamizole-induced agranulocytosis is between 0.2 an
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